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Dean's Report 2011-2012
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Generations of Leaders I 25 Shattuck Street Boston, Massachusetts 02115 www.hms.harvard.edu Dean’s Report 2011–2012 harvard medical school 29113Acvr.indd 1 12/13/11 9:54 AM

Dean’s Report 2011 I 2012 1 Driving Change. Building Momentum. Making History. Whether training tomorrow’s doctors and scientists, decoding the Since 1782, Dean Jeffrey S. Flier fundamental nature of Harvard Medical life, advancing patient care or improving health delivery systems around the world, we are never at School has been rest. Allied with some of the world’s best hospitals, the incubator of research institutes and a University synonymous with excellence, the School’s mission remains as 1 Message from the Dean bold ideas—a ambitious as it is honorable: to alleviate human suf- 8  eaching and T Learning place where fering caused by disease. Toward that goal we have made impressive strides, of which just a few are 2 Research and 1 Discovery extraordinary celebrated here. This year, the HMS community— 6 Leaders and 1 Innovators people advance nearly 11,900 faculty, several thousand medical and graduate students, postdoctoral fellows, alumni and 2 Facts and Figures 2 HMS Leadership education, health and research professionals—joined forces Preclinical Department Chairs science and with Harvard’s other schools as well as institutions in and beyond Boston, pooling their knowledge and Collaborations Across Harvard health care with creativity more fruitfully than ever before. n Two Affiliated Hospitals and Institutions unrelenting events within as many weeks underscore the power and promise of this unique HMS by the Numbers passion. community, perhaps the Fundraising greatest concentration of To view “HMS in Motion,” an exciting Highlights video surveying the biomedical intellectual past year, go to the Financial Report HMS YouTube Channel at http://ow.ly/7lphy

2 Dean’s Report 2011 I 2012 Dean’s Report 2011 I 2012 3 Hundreds celebrated the dedication of the HMS Quad on Longwood Avenue in 1906. In September, an HMS graduate won the Nobel Prize in Medicine or Physiology for co-discovering essential steps by which the immune system responds to infection. Sadly, Ralph Steinman, New Feats and Frontiers This year the HMS community saw astonishing breakthroughs. Scientists unveiled an “evolution machine” capable of speeding genetic changes in bacteria; they also traced neural networks of the brain in three dimensions. HMS Such synergy is limited only by the imagination. One multi- disciplinary team is seeking new therapeutic targets by studying how infectious bacteria evolve as they move through their host. Another is developing new genetic tests for amyotrophic lat- HMS class of 1968, died of can- and Oxford researchers published eral sclerosis, or ALS, and other cer shortly before the announce- the world’s most detailed genetic neurodegenerative disorders. For ment. Remarkably, he had de- map. In clinical medicine, noth- more information on Harvard veloped a novel immunotherapy ing captured the public’s imagina- Catalyst studies and resources, to keep his disease at bay—one tion like the first U.S. full-face visit www.catalyst.harvard.edu. based on his own research on the transplant, performed by HMS The need for leaders in medi- immune system’s dendritic cells. clinical faculty at Brigham and cine and biomedical science has Later that month, an HMS Women’s Hospital. never been greater. Our medi- student was presented with a Meanwhile, pressing health cal education programs, widely different sort of honor in im- threats—drug-resistant infec- emulated, continue to evolve. munology—the Jeffrey Modell tions, epidemics of obesity and At the same time, a revitalized Prize. This distinction, awarded Type 2 diabetes, HIV/AIDS, HMS Academy is helping faculty for the best PhD dissertation in unsustainable health care costs, continually reinvent teaching immunology at Harvard, was be- gross disparities in health methods and tools. Our gradu- stowed by a committee of expert among the rich and poor, ethical ate programs in the life sciences, faculty on Salil Garg ’12, who quandaries arising from genetic which have earned top rankings described how dendritic cells testing—remain to be solved. from the National Research digest and then process bacteria But at HMS, our power to Council, train hundreds of PhD in preparation for vanquishing convene experts from the world scientists each year, many of future invaders. Like Steinman, over enables us to make inroads whom now lead university labo- 19,4 83 Garg plans to dedicate his career against even seemingly intrac- ratories, biomedical companies, to basic science. He, too, aims to table challenges. and institutes of science and apply his discoveries to the diag- Driving such advances is academic health care centers and education. nosis and treatment of disease. Harvard Catalyst | The Harvard allied institutions. By building Like others at HMS, I am Clinical and Translational Sci- networks of researchers who A Cure for U.S. Health Care? inspired by the triumphs of our ence Center. Now in its fourth pool ideas across disciplines, we Our health care system is gravely graduates. The cycle of learning, year, this extraordinary center are collectively moving labora- ill. It also is imperiling our na- research and discovery contin- draws on the collective intellectu- tory discoveries to the patient’s tion’s fiscal health, providing less Estimated number ues, driven by successive genera- al and technological resources of of MD graduates bedside, then back to the lab for value per dollar than taxpayers tions of brilliant minds. Harvard’s 11 schools, 17 affiliated since 1782 further investigation. can sustain. To improve both

4 Dean’s Report 2011 I 2012 Dean’s Report 2011 I 2012 5 outcomes and costs, faculty in the HMS Department of Health Care Policy explore challenges and solutions for government-funded programs, private insurers and care providers. And in a major effort this year to advance a field central to our reform efforts, our faculty and community partners to discuss, collaborate and in- novate in the field of primary care at HMS and beyond. A search committee I now chair aims to identify a director of national repute for the Center in 2012. In October 2011, the Center’s and rewarding quality of care, not patient volume, quality indi- cators improved, staff burnout decreased and emergency room visits fell by 39 percent. Questing for New Medicines Basic science, clinical care: Bridg- 37 19 Leading the School’s outreach to world populations in desperate need of health care is the Depart- ment of Global Health and Social Medicine. This group promotes high-quality care through research and education, working in partner- ship with developing countries, new Center for Primary Care first Innovations Conference ing these realms is a top priority This 1.2-million-volt x-ray our clinical affiliates and the threw open its doors. No aspect drew a capacity crowd. Partici- of my deanship. Translating labo- therapy machine was the nonprofit organization Partners in most powerful of its day. of my deanship has made me pants shared practices and chal- ratory findings into new therapies The Harvard Cancer Com- Health. In resource-poor settings, prouder than this Center and lenges involving new models of is difficult and expensive. But as mission pioneered radiation including Haiti, Rwanda, Bangla- its mission to train leaders in health care delivery, virtual care the flow of new medicines slows therapy at the Collis P. desh and Uganda, HMS students primary care and health systems and team-based care. One medi- to a trickle, a central goal for the Huntington Memorial and residents develop culturally innovation, education and policy. cal home model reported that, by School must be to engage more Hospital, which merged sensitive options for delivering with Massachusetts General Launched with an anonymous lengthening appointments, en- fully in developing new therapies Hospital in 1941. care that will prevent needless $30 million gift, the Center has abling electronic communication while simultaneously supporting deaths from diseases treated easily galvanized students, residents, between doctors and patients, basic research. All HMS depart- and cheaply elsewhere. This year, Programs in Global ments—basic science, clinical Health and Social Change are research, health policy, global exploring solutions for people liv- health—have roles to play in the ing on less than $1 a day that are School’s translational mission. cost-effective, locally acceptable This year, we launched the and scalable to thousands. Fac- HMS Program in Translational ulty concentrate in areas such as Science and Therapeutics, of primary care, infectious disease, which the first signature compo- maternal and newborn health, nent is the Initiative in Systems surgery, non-communicable Pharmacology. Typically formu- diseases and health systems, to lated to impact one biological name a few. Given advances in pathway or one molecular target, biomedicine and communica- most potential drugs fail in tion, we have the opportunity to people. But the emerging field save lives anywhere in the world. of systems pharmacology strives Thanks to our success in secur- to understand a drug’s effects on ing research grants, generous phil- tissues, organs and cellular path- anthropic support and the careful ways within a living organism. stewardship of all funds, HMS The Initiative will draw together rests on stable financial ground. an unprecedented mix of cell However, given the financial chal- biologists, geneticists, systems lenges facing our country and the biologists, mathematicians, world, we continue to plan care- physicists, computer scientists fully, dedicated to ensuring that and bioengineers to explore the our first 230 years represent the precise impact of drugs on com- dawn of Harvard Medical School’s plex physiological networks long service to society. before they reach human trials. This report highlights just some of the past year’s achievements. Commencement is just the Our Global Reach Also featured are reminders of our beginning for HMS graduates, With an inclusive diverse faculty venerable history of innovation: who pursue careers in patient and a student population that in depictions of early explorers of care, education, translational and laboratory research, health 2011 represented eight countries, science and the healing arts. Their policy, biomedical industries the HMS community embraces a milestones inspire us all as we look and other spheres. world without borders. with excitement to the future. n

6 Dean’s Report 2011 I 2012 Dean’s Report 2011 I 2012 7 3,663 clinical fellows—future change agents in medicine and research—are now in Emergency medicine resident Emily Aaronson poses a question during trauma rounds at Brigham training at the School’s and Women’s Hospital. Residents, pharmacists, physical therapists, nurses and social workers gather to affiliates. discuss the holistic management of patients, including social, psycho- logical and rehabilitative needs.

8 Dean’s Report 2011 I 2012 Dean’s Report 2011 I 2012 9 Teaching and Learning Evaluation also is at the heart of two stud- ies initiated by the HMS Center for Evalua- tion, directed by Edward Krupat, the principal investigator of both studies. The first, funded Second-year medi- cal students William in 2011 by a grant from the National Insti- Johnson (left) and tutes of Health (NIH), will illuminate factors Alister Martin per- associated with HMS students’ decisions to form musculoskel- pursue careers in research, in particular those etal exams for the wrist and shoulder. of underrepresented minority students. A second study aims to identify factors most Essential to innovation in medical education closely associated with success and difficulties at HMS is the process of evaluation—of what in medical school, with the aim of identifying we do, how we do it and how best to make im- markers of potential problems and addressing provements. Anticipating a site visit last spring them proactively. from the School’s accrediting body, the Liaison Committee on Medical Education (LCME), Every HMS Student a Scholar Dean for Medical Education Jules Dienstag, the In the belief that today’s students must not Carl W. Walter Professor of Medicine, and other only master knowledge but also learn to leaders in the Program in Medical Education create it, HMS in 2011 launched the Scholars (PME) led a comprehensive self-study involving in Medicine Program, beginning with the broad participation by faculty, staff and students incoming class of 2015. This curricular addi- from the HMS Quad and our clinical affiliates. tion, directed by Gordon Strewler, professor In November 2011, the LCME reaccredited the of medicine at Beth Israel Deaconess Medical School, citing as particular strengths medical Center and master of the Cannon Society, education reform and the Principal Clinical aims to spark curiosity and a love of discov- Experience, support for the faculty’s role in ery. Students will undertake projects that teaching, and the Dean’s strategic planning run the gamut of inquiry, from molecular process. The entire HMS community shares biology to health care policy and the history credit for programmatic changes and innova- of medicine. In year four, each will work tions launched in the two-year period that with a senior faculty mentor and execute a culminated in this impressive outcome. written scholarly project. To date, 550 faculty One result of the School’s continuous self- have volunteered projects, and more than evaluation was the decision to begin building 70 faculty will serve as advisors, helping high-tech classrooms this summer, a recom- students identify and advance their projects mendation of the Task Force on Classroom to completion. Learning. In 2010, the PME also established a Course and Clerkship Review and Evaluation Center for Primary Care Committee, composed of faculty members Addressing the need to train high-caliber Schools across the from wide-ranging disciplines who are primary care physicians who will help lead reviewing the medical education curriculum the shaping of policies that will reform U.S. U.S. look to HMS as from stem to stern. health care, within its first year the Center for Primary Care has begun attracting national The first class of attention and participation. The Center is ably a standard-bearer in women admitted led by three HMS faculty members serving as 45 at Harvard Medical School interim co-directors: Andrew Ellner and David medical education. Bates, of Brigham and Women’s Hospital, 19 and Russell Phillips, of Beth Israel Deacon- ess Medical Center. This fall, an Innovation Fellows Program began supporting primary care faculty as they devote a year to research on care delivery, creating a community of clinician innovators, mentoring students and promoting cross-disciplinary collaborations.

10 Teaching and Learning Dean’s Report 2011 I 2012 11 Teaching Clinical Skills: Seeking a Better Way awarded $1.65 million through its loan- program, one of five which include systems At HMS, students are introduced to patients forgiveness programs to 2011 graduates, biology and, within the Division of Medical in week one, then build clinical skills over four chiefly those pursuing careers in public ser- Sciences, biological and biomedical sciences, years. Mentoring is key to this process, and a vice or, new this year, global health. neuroscience, immunology and virology. new Task Force on Teaching Clinical Skills is Master of Medical Sciences in Global working to ensure top-flight teaching at every HMS Academy Hones Faculty Teaching Skills Health Delivery. A new master’s degree level with the involvement of clinical faculty To help equip faculty with skills that bring out program in Global Health Delivery was ap- at the School’s affiliated hospitals and clinics. the best in medical students, the HMS Academy proved in 2011. Upon its launch, expected in In year three, known as the Principal Clinical rolled out an array of new workshops and sym- the coming year, the program will join exist- Experience (PCE), students train at a single hos- posia this year. More than 540 faculty attended ing programs in Bioinformatics, Scholars pital or health system, forging close ties with one or more sessions focused on teaching com- in Clinical Science and Clinical Investigator faculty, staff and patients. When the PCE was munication skills, evaluating learners’ clinical Training. With mentored research a major instituted in 2008, HMS launched quarterly competencies, and understanding the neuro- component, participants will study and Intersessions, bringing students engaged in biology of stress and its impact on learning. develop interventions to improve health care the 12-month PCE back to the Quad to discuss The Academy also sponsored sessions concern- delivery in resource-poor settings. Under health policy, delivery systems and medical eth- ing research on education and expanded the development are master’s programs in course, “Introduction to Clinical Investigation”; ics. These sessions provide resources for a fac- Harvard Inter-Hospital Education Collaborative, bioethics and medical education. a two-week course, “Intensive Training in Trans- ulty leader to oversee professional development in which faculty from HMS-affiliated hospitals International Partners. HMS and the Swiss lational Medicine”; and a new 40-week, free across the four-year curriculum, beginning with present their work in progress. university École Polytechnique Fédérale de course in biostatistics fundamentals. the first course of medical school, “Introduc- Lausanne (EPFL), supported by the Bertarelli Expertise in Grant Writing. In 2011, Harvard tion to the Profession,” and culminating in a Spotlight on Graduate Education Foundation, have initiated the collaborative Catalyst launched the Grant Review and Support new capstone course under development for Boot Camp for Graduate Students. To prepare HMS–EPFL Program in Translational Neuro­ Program, GRASP. This Harvard-wide initiative graduating students and designed to facilitate incoming students to analyze experimental data, science and Neuroengineering, a research aims to transition junior faculty from NIH- their transition to postgraduate training. HMS in 2011 piloted a “Quantitative Science and education initiative that aims to improve funded K01 or K23 grants to research indepen- Boot Camp.” This four-day course covered quan- quality of life for people with neurological dence, supported by R01 grants. Led by Profes- Financial Aid Opens Doors titative tools used to answer research questions. disabilities. In 2011, research projects began at sor of Medicine Steven Freedman at Beth Israel Many of our students, all of whom gain need- The course complements the “Experimental both sites. Also this year, four EPFL master’s Deaconess Medical Center, GRASP links rising Mary Ellen Avery, blind admission based on academic merit, Design Boot Camp,” which explains how to students came to HMS for translational stud- scientists to senior advisors with K24 grants. Thomas Morgan Rotch require scholarships and loans to attend Professor of Pediat- develop and test hypotheses. Helping design ies in neuroscience and neuroengineering, Also offered is “Elements of Grant Writing.” HMS. In academic year 2011–2012, about 84 rics, Emeritus, with a these courses are members of the Curriculum focusing on projects such as the underlying percent will receive more than $31 million patient at Children’s Fellows Program, a unique three-year certificate mechanisms of, and treatment for, hearing Continuing Medical Education in such funding from institutional, federal Hospital Boston. Avery program that prepares PhD scientists to educate loss. Collaborative exchange programs in Italy, The Department of Continuing Education discovered that respi- and private sources; nearly $15 million of this ratory distress syn- future teachers and administrative leaders in Dubai and Portugal also continued to thrive. provides opportunities for health profession- support represents institutional scholarships drome in premature science. These initiatives are flagship efforts of als to maintain skills, increase knowledge bestowed by the School. HMS ranks among infants arises from a the Longwood Program in Graduate Educa- Harvard Catalyst Postgraduate Education and competence, and improve performance. the top five U.S. medical schools for these lack of lung surfactant, tion, made up of the nine life-sciences graduate One goal of Harvard Catalyst | The Harvard Faculty Dean for Continuing Education Sanjiv a finding that led to a awards. To lower the burden of debt that programs at HMS, the Harvard School of Public Clinical and Translational Science Center, Chopra, HMS professor of medicine, stresses therapy that has since can steer students away from highly reward- saved hundreds of Health (HSPH) and the Harvard School of directed by Lee Nadler—dean for clinical and “the four Rs”: rigor—the highest standards ing but less lucrative specialties, the School thousands of lives. Dental Medicine (HSDM). translational research, and the Virginia and of evidence-based teaching and innovation; Bioinformatics and Integrated Genomics. D.K. Ludwig Professor of Medicine—is to reputation—that is, enhancing the School’s This year, HMS Dean for Graduate Education train physicians and scientists in the funda- stature; reach—making instruction accessible David Golan and Associate Dean for Basic mentals of clinical and translational research. and affordable; and research—ensuring that Graduate Studies David Cardozo laid the Training Young Investigators. In the past teaching methods help participants acquire groundwork for ensuring the successful launch two years, 750 MDs and PhDs have gravitated knowledge and put it into practice. In fiscal 59 of the Bioinformatics and Integrated Genom- to courses offered by the Harvard Catalyst year 2011, more than 76,000 physicians and ics Program (BIG). postgraduate education program, directed by other health professionals took advantage of 19 Stephen Pomedli, This interdepartmental Elliott Antman, associate dean for clinical and class of 2011, became more than 715 courses and conferences offered graduate program is translational research and professor of interested in primary at HMS, affiliated hospitals and six partnering now accepting applica- medicine; James Ware serves as associate care at HMS and is U.S. medical schools. More than 65 courses tions for admission in director and is also HSPH associate dean for now pursing a offered online drew over 41,000 participants residency in family fall 2012. Students will clinical and translational science and the and community from 171 countries. According to an online sur- be co-admitted into Frederick Mosteller Professor of Biostatistics. medicine at the vey, more than 98 percent would recommend BIG and a “home” PhD Postgraduate offerings include a one-week University of Toronto. these courses to colleagues. n

Dean’s Report 2011 I 2012 13 Research and Discovery Robust Federal Support Under the direction of Executive Dean for Re- search William Chin, the Bertarelli Professor of Translational Medical Science and a leader in pharmaceutical discovery, the School’s research enterprise continues to flourish. The federal government is the primary and essential source of research dollars at HMS and its 17 affiliated hospitals and research In 2011, thousands of discoveries sprang from institutes. Budgets, which continue to face the HMS Quad and affiliate laboratories. pressure, are concentrated in translational While all build on accumulated insights, many research that moves laboratory findings into also represent seismic shifts in thinking. medical practice. HMS, where investigators For example, HMS researchers recently are more successful than most in securing upended long-held assumptions about grants, is positioning programs to maximize the structure of the prime protein culprit government sponsorship in this arena while involved in Parkinson’s disease, a discovery also turning to new non-federal sources. likely to redirect efforts to slow or prevent In fiscal year 2011, HMS, including HSDM, neurodegeneration. Another team elucidated headed by Dean Bruce Donoff, received the molecular basis of innate mammalian $313.6 million in sponsored programs, behavior when they identified an olfactory 38 percent of Harvard University’s spon- chemical secreted by predators that triggers sored portfolio. National Institutes of Health rodents’ instinctual flight. Also this year came grants totaled $266.5 million, with all federal the finding that stem cells in bone marrow awards reaching $276.3 million. American can stimulate the heart to regenerate muscle Recovery and Reinvestment Act (ARRA) following a heart attack. For more discoveries funds, at $47.1 million, created 234 new jobs by HMS faculty, visit www.focushms.com/ at HMS and collaborating Harvard schools. category/research/. Harvard‘s Our constellation of research institutions Collaborating Across the Quad includes the Harvard Stem Cell Institute July 2011 marked the launch of the new and the Broad Institute of MIT and Harvard, Department of Microbiology and Immunobi- biomedical Guided by William where many HMS faculty hold appoint- ology, chaired by John Mekalanos, the Adele Porter, HMS began ment; also the Wyss Institute for Biologically requiring students to Lehman Professor of Microbiology and Mo- Inspired Engineering, where, for example, researchers perform and discuss lecular Genetics. This group brings together researchers have developed a nano-scale tool experiments in faculty who explore the biology of pathogenic that builds complex structures from biomol- physiology. This new viruses and bacteria (including the lethal approach empha- devise leading- ecules at a rate 10,000 times faster than cur- sized observation strain of the cholera bacterium now devastat- rent methods and holds promise for treating rather than didactic ing Haiti), microbial agents’ host organisms, 99 and diagnosing disease. teaching alone. the immune system, and their interactions edge therapies during infection. A major goal of joining these infectious disease experts, pathologists, 18 geneticists and surrounding clinical affiliate and decipher partners is to battle multidrug-resistant TB, HIV/AIDS, and other emerging diseases with At the Nikon Imaging antimicrobial drugs and vaccines. Integral to the biological Center at HMS, where the department is the newly formed Division researchers logged 21,300 of Immunology, a unifying entity serving hours in 2011, fluorescence immunologists on the Quad. basis of life. microscopy and other tech- nologies explore cellular processes and structures Translational Science and Therapeutics (here, a pine stem). If the promise of personalized medicine is to be fulfilled, academe must play a larger role in therapeutic discovery by providing a

14 Research and Discovery Dean’s Report 2011 I 2012 15 deeper understanding of how the normal body More than 1,100 investigators have enrolled works and the root causes of disease. Yet the in the Harvard Catalyst Clinical Research Cen- number of new drugs is declining, even as the ter, which in academic year 2011 encompassed pharmaceutical industry struggles to serve the more than 30,000 patient visits at five sites. needs of patients who are divided increasingly Directed by Anne Klibanski, associate dean into smaller, better-defined groups requiring for clinical and translational research and the discrete molecularly targeted therapies. Laurie Carrol Guthart Professor of Medicine, HMS can lead by opening doors to novel the program makes available to all clinical ways of tracing diseases to their origins—by investigators services in research nursing, identifying new biomarkers and develop- In the lab of HMS class immunologists. Within that effort, the nutrition and protocol development. A single ing new animal models, for example, and by Professor of Neuro- Harvard Institute of Translational Immunology, online system streamlines the protocol review biology David Corey, maturing disciplines such as chemical biology HITI, targets immune-mediated diseases. In fis- process. A centralized laboratory reduces a probe delivers and systems pharmacology. Announced this movements of about cal year 2011, HITI drew together a community costs, and a microgrant program in 2011 year, the Initiative in Systems Pharmacology, a millionth of an inch of experts in immune and inflammatory sys- awarded up to $5,000 to 20 junior investiga- headed by Marc Kirschner, the John Franklin to cells from the inner tems, host defense, stem cell biology and tissue tors for tests needed for their studies. Enders University Professor of Systems Biology ear, mimicking sound engineering. With funding from the Leona M. Through the Community Health Innova­ vibrations. and chair of that department, will explore the and Harry B. Helmsley Charitable Trust, HITI tion and Research Program, known as complex interactions between new candidate awarded more than a dozen competitive grants CHIRP, Harvard Catalyst engages with both drugs and living biological systems. to teams focused on two autoimmune disease the state and community partners. Faculty and Federal regulatory agencies too must work areas: Type 1 diabetes and Crohn’s disease. By students work to translate scientific evidence with academe and industry to ensure public forming new communities centered around into effective health policies through research safety while encouraging innovation. To avoid specific diseases, HITI is fostering key collabo- and training activities. With the Massachusetts potential conflicts of interest, HMS is complet- rations and the sharing of patient samples. Department of Public Health, for example, in ing the education and implementation phase 2010 CHIRP analyzed the impact of restrict- of its revised Policy on Conflicts of Interest Building Synergies ing sales of snack foods and soda in schools as and Commitment, codified to ensure that our A model vehicle for encouraging collabora- well as barriers to such restrictions, and is now research activities meet the highest possible tion among scientists in disparate fields, evaluating new state regulations on competi- standards of integrity and transparency. Harvard Catalyst continues in year four to tive food sales. CHIRP also is helping commu- advance translational and patient-based stud- nity health centers become more fully engaged Immunology: Building on Strength ies by fostering interactions among thou- in research and in translating evidence into Harvard Immunology enters its second year le- sands of faculty across HMS, its affiliates and practice; a community advisory board has 32 veraging the expertise of the University’s world- other Harvard schools, linking resources with Investigators in academe and industry In Professor of been pivotal in providing direction. Several researchers who have the imagination to ask are continually developing unique strains of Neurobiology Clay planning grants have been funded with com- 19 the right questions. microorganisms, animal models, laboratory Reid’s lab, postdoc munity partners, including grants to improve Mark Andermann One of the greatest challenges in clinical equipment, reagents and other specialized uses fluorescence mi- access to care. For maximum translational research is compiling large groups of pa- resources. These valuable tools often are croscopy to monitor impact, a key goal is to increase coordination tients who meet a certain set of criteria—for invisible to researchers elsewhere. To make changes in individual among all stakeholders—community groups, example, men over age 60 with stage 3 colon them widely available for potential sharing, neurons in the brain’s health care systems and policymakers. visual cortex. He aims cancer in remission, taking certain medica- Harvard Catalyst formed the “eagle-i Con- to cast light on how tions and showing particular lab results. To sortium,” a group of nine U.S. universities Accelerating Impact neurons’ responses compile a pool of de-identified patient data that created an online database of all types of are affected during To translate discoveries forged at the research from multiple institutions, Harvard Cata- biomedical research resources searchable by learning in models bench into solutions for intractable medical Harvey William 5,204 lyst developed the Shared Health Research scientists anywhere. Inventory will expand as of diseases such as problems, Harvard’s Office of Technology Cushing, father of Alzheimer’s. modern neurosurgery, Information Network, or SHRINE, a web- other institutions join. Development speeds the development of tools, at the Peter Bent based search tool that enables investigators to assays, equipment and therapies in three ways: Brigham Hospital, search multiple hospital databases of clinical by protecting intellectual property; by fostering where he was chief Estimated total postdoctoral fellows at HMS and affiliates of surgery. In 1980, care information at the same time. Led by creative alliances with strong industry collabo- the hospital merged Isaac Kohane, the Lawrence J. Henderson rators through sponsored research agreements with the Robert Breck Professor of Pediatrics, and directed by and licensing transactions for new inventions; Brigham Hospital and Douglas MacFadden, director of informatics and by providing competitive grants for proof- the Boston Hospital for Women to form technology, SHRINE networks are being used of-concept studies through the Accelerator Brigham and Women’s nationally. The Harvard network includes five Fund. For more information and examples of Hospital. affiliated hospitals. licensed products, visit otd.harvard.edu. n

Dean’s Report 2011 I 2012 17 Leaders and Innovators Expediting Promotions. Among priorities in academic year 2010–2011 was streamlin- ing the faculty promotions process while maintaining rigorous evaluation standards. The new, expedited process consolidates steps formerly taking place at HMS and the hospitals into a single, transparent and more efficient model. The average length of evaluation is now less than one year. Faculty promotions increased 28 percent over the An outstanding faculty of nearly 11,900 on previous year, while promotions to the rank the HMS campus and its 17 affiliated institu- of professor rose by 43 percent. Promotion tions must be nurtured and supported as committees now use a paperless system, and they strive to test ideas through experimenta- faculty members can monitor the progress of tion and pass their knowledge to generations their evaluation on a secure website. Encour- of students. Overseeing this effort is Dean for aged to think beyond traditional definitions Academic and Clinical Affairs Nancy Tarbell, as to what constitutes top scholarship, faculty the C.C. Wang Professor of Radiation Oncol- may submit, in addition to peer-reviewed ogy, herself a physician and champion of publications, materials such as course syllabi, faculty development, including mentoring of nationally adopted guidelines for patient care, women, minorities and of junior faculty and and novel methods or technologies that have the expansion of professional opportunities had major, demonstrable impact. for faculty at every rank. Commitment to Diversity. In 2011, the num- ber of women professors at HMS increased Recruitment and Promotion to 150; 16 percent of the senior faculty are At HMS, recruiting and retaining the best now female. Minority faculty now constitute faculty are paramount goals. In 2011, under the 5 percent of all faculty and nearly 5 percent leadership of Dean for Faculty Affairs Maureen of promotions at every rank including that Connelly, HMS made notable strides in faculty of professor. The second and third African 23 recruitment, retention and career advancement. American women ever appointed HMS pro- HMS is a global fessors were promoted in this academic year. Searches, Recruits, Orientation. To expe- 19 dite searches for senior faculty, HMS and center of creativity its affiliates now fluidly share information among the Dean’s Office, department leaders and governing boards. In 2011, the faculties and innovation of Medicine and Arts and Sciences welcomed to Global Health and Social Medicine David where faculty push Jones ’01, the first A. Bernard Ackerman Professor of the Culture of Medicine and an expert on the history of health inequities. the boundaries of The School’s recruitment efforts also have successfully attracted several outstanding their disciplines in junior faculty, with invitations accepted by Walter Bradford scholars at the top of their fields to join the Cannon (right), George departments of Genetics, Health Care Policy labs, classrooms Botswana native Neo Tapela, Higginson Professor of and Neurobiology. Common review standards HMS ‘06 (in Haiti) is an instruc- Physiology at HMS, tor of medicine in the Division with acclaimed are being fine-tuned for appointing junior and the field. of Global Health Equity with physiologist Ivan faculty, who are welcomed to HMS through Brigham and Women’s Hospital Pavlov. Each made key orientation events at which they hear from and Partners in Health in Rwanda. discoveries about the Dean Jeffrey S. Flier, senior administrators association between emotions, psychology and panels of senior faculty, and discover an and physiology. array of career resources.

18 Leaders and Innovators Dean’s Report 2011 I 2012 19 Fostering Diversity Inclusion Paul Zoll, chief of research and health care delivery. More than issue of The New Yorker, “A Child in Time: Poor health outcomes for African Americans, cardiac services at 86 percent serve on national, state and local New Frontiers in Treating Premature Babies,” the former Beth Israel Hispanic Americans, American Indians and committees and advisory boards; 64 per- that describes how physicians now save many Hospital, was the first Alaska Natives, Asian Americans, Native to use external defibril- cent have published scholarly works; and 71 infants born in a perilous state. Hawaiians and Pacific Islanders are apparent lation to regulate heart percent have held academic appointments at Office for Diversity Inclusion and Com- when their health indicators are compared rhythms in patients. schools of public health and medicine. Fif- munity Partnership Faculty Fellowship. This with the rest of the U.S. population. These In 1996, Beth Israel teen alumni are now at HMS as associate or two-year, non-degree fellowship, sponsored merged with Deacon- populations experience higher rates of illness ess Hospital to form assistant professors or instructors. in partnership with HMS-affiliated hospitals and death related to health conditions such Beth Israel Deaconess The Commonwealth Fund Harvard Uni- and the Provost’s Office at Harvard, enables as heart disease, stroke, specific cancers, Medical Center. versity Fellowship in Minority Health Policy HMS junior faculty to pursue activities that diabetes, HIV/AIDS, asthma, hepatitis B and (CFHUF). Celebrating its 15th year in 2011, promote their professional development. obesity. To elevate the quality of care available this degree-granting fellowship, supported by Francisco Quintana, assistant professor of to minority, disadvantaged and underserved the Commonwealth Fund, prepares physi- neurology at Brigham and Women’s Hospi- populations, the HMS Office for Diversity cians to expand access to high-quality care tal, who is completing his second fellowship Inclusion and Community Partnership for minority and other vulnerable popula- year, has identified a potential therapeutic (DCP), headed by Dean Joan Reede, associate tions. The yearlong opportunity comes under target for the modulation of the immune professor of medicine, engages in a range the direction of DCP’s Minority Faculty response in human autoimmune disease of minority health fellowship programs that Development Program at HMS in collabora- through a recently awarded R01 grant provide advanced training to physicians. tion with HSPH and the Harvard Kennedy from the National Institute of Allergy and Between 1996 and 2012, nearly 100 School. Among many distinguished alumni Infectious Diseases. participants have achieved professional suc- is Roderick King, a 1998 fellow, now an cess: currently 53 percent hold positions at instructor in social medicine at HMS and Honors and Awards academic institutions; 25 percent work the senior faculty member at the Disparities In addition to the HMS faculty cited below, hundreds public sector; and 22 percent hold private- Solutions Center at Massachusetts Gen- more are honored annually by professional societies, sector posts. Collectively they advance health eral Hospital, who as a 2011–2012 Fulbright residents and students is a theme, as is faculty Selwyn Rogers with institutions, communities and governments worldwide. policy, public health, and minority health NEXUS Scholar is guiding a project aimed at development and research focusing on health fourth-year student 63 Bethany Strong. Rog- Two HMS Faculty Named developing leaders to improve the health of disparities such as postpartum depression–as- ers, an HMS Faculty Caribbean populations. sociated child health outcomes, with a focus University Professors 19 Fellow funded by the Joseph L. Henry Oral specifically on sociodemographic and stressor Center of Excellence The Harvard University Professorship, established in Health Fellowship in variables across women by race and ethnicity in Minority Health and 1935, recognizes individuals working on the frontiers Minority Health Policy. and a study of the spread of medical mistrust Health Disparities from of knowledge in ways that span traditional boundaries 2003 to 2005, is an Marking its sixth year at and inaccurate health information in the social associate professor of between academic disciplines. This past year, two HMS HMS, this degree-grant- networks of African Americans with HIV. surgery and division faculty members received this distinction, joining Marc ing program, supported Harvard Catalyst Faculty Fellowship. This chief for Trauma, Burns Kirschner, the John Franklin Enders University Professor by the Dental Service two-year, non-degree fellowship frees junior and Surgical Critical of Systems Biology and chair of that department, in Care at Brigham and of Massachusetts/Delta faculty from clinical and teaching demands at holding this highest faculty honor, of which there are Women’s Hospital. His Dental Plan, is named for a revered profes- a key point in their careers, allowing them to research focuses on im- only 25. sor emeritus at HSDM who died in 2011. conduct translational research. Appointed to proving care quality for Paul Farmer, chair of the HMS Department of The program cultivates leaders in minority this fellowship in 2010 is neonatologist Camil- minority populations. Global Health and Social Medicine and co-founder oral health determined to enlarge the health ia Martin, assistant professor of pediatrics at of Partners In Health, is the first Kolokotrones Uni- system’s capacity to address special needs Beth Israel Deaconess Medical Center. Martin versity Professor. Farmer, a physician-anthropologist, of minority and disadvantaged populations. was featured in an article in the Oct. 24, 2011, has revolutionized community-based strategies for Brian Swann, a 2008 fellow, is currently the treating infectious diseases in developing countries, 11,860 chief of dental services at Cambridge Health champions health as a human right, and studies the Alliance and clinical instructor in oral health role of social inequalities in determining disease Total faculty on policy and epidemiology at HSDM. the HMS campus distribution and outcomes. Center of Excellence in Minority Health and affiliates Douglas Melton, co-chair of Stem Cell and Regen- and Health Disparities. Building on existing erative Biology (SCRB), a department administered by educational programs at HMS, this virtual HMS and the Faculty of Arts and Sciences (FAS), is the center works to enhance the academic perfor- Xander University Professor. Melton, also the Thomas mance of underrepresented minority students, Dudley Cabot Professor of the Natural Sciences, has been who make up 19 percent of the 2011 entering a driving force behind Harvard’s ascendancy in stem cell class. Cultural competence training for faculty, research and co-chairs the Harvard Stem Cell Institute.

20 Leaders and Innovators Dean’s Report 2011 I 2012 21 Gary Ruvkun Receives 2011 Dan David Prize Sidney Farber showed to a basic scientist and a clinician, both pioneers in for the first time that This international $1 million award, endowed by the a drug could combat bioengineering. HMS Dean Jeffrey S. Flier chairs the Dan David Foundation at Tel Aviv University, was childhood leukemias Alpert Foundation’s scientific advisory com­ ittee, which m awarded to Gary Ruvkun, HMS professor of genetics and other non-solid selects recipients of this prestigious award. in the Department of Molecular Biology at Massachu- tumors. Farber Robert Langer, senior lecturer on surgery at HMS founded the Children’s setts General Hospital. The prize recognizes innovative and the David H. Koch Institute Professor at MIT, is Cancer Research research that cuts across traditional paradigms. Having Foundation, forerunner known for advancing drug delivery and tissue engineer- worked to define the genetic basis of aging, Ruvkun has of Dana-Farber Cancer ing. He has developed polymers to deliver drugs at discovered in animal models a set of hormonal signals Institute. controlled rates and has engineered blood vessels and and pathways that regulate aging and lifespan. vascularized skeletal muscle tissue. The world’s most cited engineer, Langer holds more than 800 granted or Matthew Nock Named MacArthur Fellow pending patents. Matthew Nock, a professor of psychology at FAS Alain Carpentier, head of the Department of Car- who studies suicide and self-injury in adolescents and diovascular Surgery at the Hôpital Européen Georges- adults, received a $500,000 “genius” grant from the Pompidou in Paris, is recognized for developing and John D. and Catherine T. MacArthur Foundation. In a implanting the first successful artificial bronchus, saving study supported by Harvard Catalyst, Nock collaborated the lung of a patient with cancer. He also developed with the Mass General inpatient psychiatric unit. By the first artificial valve for patients using animal tissues cidating mechanisms that maintain genomic stability combining epidemiology, lab experiments, mental processed to prevent immunological reaction and is in mammalian cells, specifically B and T lymphocytes. health associations and biological and psychological a lead developer of a fully implantable artificial heart George Daley, HMS professor of biological assessments, he is making breakthroughs in predicting soon to enter clinical trials. chemistry, molecular pharmacology and pediatrics, is and preventing suicide. the Samuel E. Lux IV Professor of Hematology/Oncology Rolf Luft Award to Jeffrey Flier at Children’s. Daley, a pioneer in stem cell research, is Alpert Prize Honors The 2011 Rolf Luft Award was awarded to HMS Dean known for his work in chronic myeloid leukemia, caused Bioengineering Luminaries Jeffrey S. Flier by the Karolinska Institute for his by genetically defective stem cells, and in somatic cell Created to reward scientists whose discoveries have seminal contributions to understanding the physiology of reprogramming to model human disease. He aims to made great progress in new therapies for a wide range insulin and leptin, and the mechanisms underlying defec- translate insights in stem cell biology into cellular thera- 60 of diseases, in 2011 the Warren Alpert Prize was awarded tive actions of these hormones in metabolic diseases. pies for degenerative, malignant and genetic diseases. Atul Gawande, associate professor of surgery Eight Named 19 at Brigham and Women’s and of health policy and to Institute of management at HSPH, is devising clinical-system Medicine innovations to improve patient outcomes, such as the In recognition of World Health Organization Safe Surgery Checklist. He exceptional scientific is developing a safe-childbirth checklist and studying achievement and com- low-cost pulse oximetry in developing countries. He Top left, left to right: JoAnn Manson, the Michael and Lee Bell Profes- mitment to service, also directs the Risk Management Foundation/Harvard Arundhati Ghosh, HMS sor of Women’s Health at HMS, professor of epide- instructor in surgery eight faculty members were among 65 named in Surgical Chiefs Patient Safety Collaborative. miology at HSPH, and chief of preventive medicine at at Cambridge Health 2011 to the Institute of Medicine, the health arm of Sharon Inouye, HMS professor of medicine, is a Alliance, with mentee Brigham and Women’s, leads high-impact randomized the National Academy of Sciences. member of the Division of Gerontology at Beth Israel Vanessa Reddit, who clinical trials and translational research on the preven- Margarita Alegria, HMS professor of psychol- Deaconess Medical Center and director of the Aging nominated Ghosh for tion of cardiovascular disease, diabetes and cancer ogy in the Department of Psychiatry, directs the Brain Center in the Institute for Aging Research at her 2011 Young Mentor in women, including the Women’s Health Initiative, Award. Above, Richard Center for Multicultural Mental Health Research at Hebrew SeniorLife. Her studies of delirium in the elderly Grand, professor of Nurses’ Health Study, the Women’s Folic Acid Study, Cambridge Health Alliance. An expert on dispari- have influenced hospital care worldwide. She leads the pediatrics at Children’s and the new VITamin D and OmegA-3 TriaL (VITAL). ties in mental health and substance abuse services Successful Aging after Elective Surgery (SAGES) study. Hospital Boston, was James Thrall, the Juan M. Taveras Professor of for minority populations and leader of the National Jay Loeffler, the Herman and Joan Suit Profes- among four who Radiology and head of the Department of Radiology received the William Latino and Asian American Study, she aims to sor of Radiation Oncology, is chief of the Department at Mass General, is an expert in nuclear medicine and Silen Lifetime Achieve- improve service access, equity and quality for of Radiation Oncology at Mass General. Specializing ment in Mentoring nuclear radiology, with clinical interests in nuclear disadvantaged populations. in neuro-oncology, Loeffler has devoted his career to Award in 2011. cardiology, positron emission tomography scanning and Frederick Alt is HMS professor of genetics and pioneering radiation delivery techniques, including skeletal scintigraphy. He oversees the Massachusetts the Charles A. Janeway Professor of Pediatrics at improvements in stereotactic radiosurgery and proton General Hospital Imaging Center. Children’s Hospital Boston. He is also president of the therapy, to target and destroy primary and secondary Immune Disease Institute and director of its Program malignant brain tumors as well as a wide variety of For a more comprehensive but by no means exhaustive list in Cellular and Molecular Medicine. The Alt lab is elu- benign tumors. of faculty honors and awards, visit www.focushms.com/.

230 Dean’s Report 2011 I 2012 23 Facts and Figures HMS LEADERSHIP PRECLINICAL DEPARTMENT CHAIRS Jeffrey S. Flier, MD ADMINISTRATIVE Joan Brugge, PhD Dean of the Faculty of DEANS Louise Foote Pfeiffer Professor of Cell Biology Medicine Chair, Cell Biology Richard G. Mills, JD ACADEMIC DEANS Paul Farmer, MD, PhD Executive Dean for Kolokotrones University Professor of Global Health Administration and Social Medicine William W. Chin, MD Wesley Benbow, MBA Chair, Global Health and Social Medicine Executive Dean for Associate Dean for Research Michael Greenberg, PhD Finance and Chief Nathan Marsh Pusey Professor of Neurobiology Maureen Connelly, Financial Officer Chair, Neurobiology MD, MPH Gretchen Brodnicki, JD Dean for Faculty Affairs Stephen Harrison, PhD Dean for Faculty and Giovanni Armenise–Harvard Professor of Basic Jules Dienstag, MD Research Integrity Biomedical Science Dean for Medical Judith Glaven, PhD Acting Chair, Biological Chemistry and Molecular Education Associate Dean for Basic Pharmacology David E. Golan, and Interdisciplinary Marc Kirschner, PhD MD, PhD Research John Franklin Enders University Professor of Dean for Graduate John Halamka, MD Systems Biology Education Chief Information Officer Chair, Systems Biology Lee Nadler, MD Barbara McNeil, MD, PhD Dean for Clinical and Lisa Muto, PhD Ridley Watts Professor of Health Care Policy Translational Research Associate Dean for Chair, Health Care Policy Institutional Planning Nancy Oriol, MD and Policy John Mekalanos, PhD Dean for Students Adele Lehman Professor of Microbiology and By any measure, Susan Rapple Joan Reede, MD, MS, Molecular Genetics Dean for Resource MPH, MBA Chair, Microbiology and Immunobiology Development Dean for Diversity and HMS is thriving, Doug Melton, PhD Community Partnership Richard Shea Xander University Professor Associate Dean for Nancy J. Tarbell, MD David Scadden, MD Physical Planning and with a distinguished Dean for Academic and Gerald and Darlene Jordan Professor of Medicine Facilities Clinical Affairs Co-chairs, Stem Cell and Regenerative Biology Julie Stanley Clifford Tabin, PhD faculty, visionary HARVARD SCHOOL Chief Human George Jacob and Jacqueline Hazel Leder Professor OF DENTAL Resources Officer of Genetics MEDICINE Chair, Genetics leadership and an Gina Vild Associate Dean for R. Bruce Donoff, Communications and COLLABORATIONS ACROSS HARVARD DMD, MD unparalleled network External Relations Dean and Chief Broad Institute of MIT and Harvard
 Communications Officer Harvard Catalyst
 of collaborators. Harvard Stem Cell Institute
 Wyss Institute for Biologically Inspired Engineering Harvard Medical School marks its 230th year in 2012.

14% 40% 46% 14% 24 Facts and Figures 14% Dean’s Report 2011 I 2012 25 25% 24% AFFILIATED HOSPITALS AND INSTITUTIONS FUNDRAISING HIGHLIGHTS FINANCIAL REPORT 3% Beth Israel Deaconess 5% Medical Center
 Harvard Medical School depends upon thousands Harvard Medical School ended fiscal year 2011 with Total operating expenses rose by 6 percent, to Brigham and Women’s Hospital
7% of friends, alumni, organizations, faculty and staff to an increase in net assets of $0.9 million, a significant $654.4 million, largely due to higher grant volume in Cambridge Health Alliance
 advance the School’s groundbreaking work in biomedical improvement over 2010. sponsored research, the accounting restatement for Children’s Hospital Boston
 research and its unparalleled programs in medical and Operating revenues totaled $655.3 million, an in- HHP and new scientific collaborations across Harvard Dana-Farber Cancer Institute graduate education. In fiscal year 2011, gifts and pledges crease of 11 percent. Sponsored research revenue grew University. Overall growth in expenditures was partly Forsyth Institute
 56% to the School totalled $95 million. To read and download by 9 percent, largely due to continued success in obtain- offset by a reduction in annual debt service following a 29% Harvard Pilgrim Health Care
 the School’s annual Honor Roll of Donors, ing federal stimulus funding for research through the strategic outlay in 2010 to lower total debt. Hebrew SeniorLife
 published by the Office for Resource American Recovery and Reinvestment Act. Other fac- HMS continues to make strides towards a sustain- Joslin Diabetes Center
 Development, visit http:// tors contributing to this positive scenario were a change able financial future. At the same time, the School $113,763,436 Judge Baker Children’s Center
 give.hms.harvard.edu/ in accounting for Harvard Health Publications (HHP), remains committed to providing an affordable education Massachusetts Eye and Ear Infirmary
 honor-roll. philanthropic support for the new Center for Primary for students, and to investing in its world-class faculty, $97,603,850 $ 94,685,992 Massachusetts General Hospital
 Care and support from School-affiliated institutions. laboratories and facilities. $87,107,000 McLean Hospital
 Mount Auburn Hospital
 FY 2011 OPERATING REVENUE 3% 5% Schepens Eye Research Institute
 3% 5% Spaulding Rehabilitation Hospital
 8% 7% Veterans Affairs Boston Healthcare System 8% 7% Research grants and contracts $304,521,297 46% Endowment income $160,414,007 14% 25% 14% FY40% FY FY FY Other revenues (*) 40% $92,430,535 14% 46% 14% HMS BY THE NUMBERS 46% 14% 11 10 09 08 Rental income $46,663,460 7% 14% 1 Message from 14% Gifts for current use $33,703,690 5% the Dean Total faculty 11,860 I Tenured and tenure-track faculty Tuition (Net) $17,563,990 3% 25% on the HMS campus, in 9 preclinical departments TOTAL HMS GIFTS AND PLEDGES 25% 24% 24% 8  eaching 166 I Voting faculty, campus and affiliates 4,980 T and Total $655,296,979 Learning Full-time faculty, campus and affiliates 8,924 FY11 $94,685,992 FY09 $97,603,850 FY10 $113,763,436 FY08 $87,107,000 (*) Includes continuing medical education, publications and royalties 2 Research Nobel Prizes (Medicine or Physiology; Peace) 1 and 9 prizes; 15 recipients I Howard Hughes Medical Discovery I Institute investigators 30 Members, Institute of 3% FY 2011 OPERATING EXPENSES 3% 1 Medicine 115 I National Academy of Sciences 62 6 Leaders and 5% 5% 7% 7% 8% Innovators MD students 709 I Total PhD students 582 Total Personnel cost $265,286,530 40% *MD-PhD Basic sciences 150 I Social sciences 19 Supplies and other expenses $155,028,253 24% 14% 2 Facts and(*included in MD and PhD totals) Total DMD 2 Figures I Plant operations $90,082,619 14% 40% 46% students 150 I Trainees (residents and postdoctoral HMS Leadership Subcontracts 56% $92,406,062 14% 56% 29% 14% fellows) 9,376 29% Debt service (principal and interest) $51,568,546 8% Preclinical Entering MD students, 2011: Total $654,372,010 24% Department (includes 13 MD-PhD) 165 I Applicants 5,435 MD Chairs $113,763,436 $113,763,436 Collaborations 223 (4.1%) I Matriculated (includes 13 I Admitted MD-PhD) 165 I Men 88 (53%) I Women 77 (47%) $97,603,850 $ 94,685,992 $97,603,850 Across Harvard $ 94,685,992 Underrepresented in medicine (African American, $87,107,000 $87,107,000 Affiliated Native American, Hispanic) 31 (19%) I Asian 56 (34%) Hospitals HMS GIFTS AND PLEDGES BY PURPOSE Credits: 3% Entering PhD and DMD students, 2011: and Institutions 5% Writing and editing by Karin Kiewra and Christine Paul, design and art direction by Paul DiMattia, photo management and editing by PhD 105 I DMD 35 I Teaching/Research 56% 7% Angela Alberti; line editing, fact checking and proofreading by Angela Alberti, R. Alan Leo, Jake Miller; printing by Kirkwood Printing; HMS by the Professorships/Faculty 29% Additional joint-degree programs: photography by Steve Gilbert, Justin Ide, J. Kiely Jr., Matt Lester, Rose Lincoln, Steve Lipofsky, Mark Ostow, Lauren Piedmont, Numbers Discretionary/Unrestricted 7% MD-MBA; MD-MPH; MD-MPP Len Rubenstein, John Soares, Jeff Thiebauth, Josh Touster; historical photos and research courtesy of Jack Eckert and Dominic Hall, Financial Aid/Student Support 5% Harvard Medical Library/Francis A. Countway Library of Medicine, the Ruth and David Freiman Archives at Beth Israel FY Deaconess Fundraising school alumni 9,582 (MD and MMS degrees) Medical Other 3% FY FY FY FY 56% FY FY FY Medical Center, Dana-Farber Cancer Institute, Richard Light, Georgia Litwack and the Boston Herald. 11 10 09 29% 08 Highlights 11 10 09 08 Produced by the Office of Communications and External Relations; Gina Vild, Associate Dean of Communications and External Relations and Financial Report Chief Communications Officer, 107 Avenue Louis Pasteur, Suite 111, Boston, MA 02115, (617) 432-0442, communications@hms.harvard.edu 992

Generations of Leaders I 25 Shattuck Street Boston, Massachusetts 02115 www.hms.harvard.edu Dean’s Report 2011–2012 harvard medical school 29113Acvr.indd 1 12/13/11 9:54 AM

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